Our laboratory is devoted to the analysis
of pathways involved in the initiation, progression, and maintenance
of cancer. Using mouse models
and both human and mouse primary cells, our goal is to understand
oncogenic pathways in tumor cells as well as the role of the
tumor microenvironment during cancer progression. We also use
various model systems to understand how tumors respond to chemotherapy
and how they become resistant. We rely on functional genomic
approaches including microarrays and high-throughput screens
to identify genes that are relevant to cancer pathogenesis and
treatment. Current research interests include pediatric sarcomas,
lung cancer pathogenesis and chemotherapy resistance.