Our laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer. Using mouse models and both human and mouse primary cells, our goal is to understand oncogenic pathways in tumor cells as well as the role of the tumor microenvironment during cancer progression. We also use various model systems to understand how tumors respond to chemotherapy and how they become resistant. We rely on functional genomic approaches including microarrays and high-throughput screens to identify genes that are relevant to cancer pathogenesis and treatment. Current research interest include pediatric sarcomas and lung cancer pathogenesis and chemotherapy resistance.